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CEFACLOR - REMEDLOR

remed order

 

50mg/mL Granules for Suspension (Oral Drops)
250mg/5mL Granules for Suspension

 

FORMULATION:
Each mL contains:
Cefaclor (as monohydrate)-50mg

Each 5mL (1 teaspoonful) contains:
Cefaclor (as monohydrate)-250mg

 

DESCRIPTION:
Cefaclor is a semisynthetic second generation cephalosporin antibiotic.  It is chemically designated as 3-Chloro-7-D (2-phenylglycinamido)-3-cephem-4carboxylic acid monohydrate.  Its empirical formula is C15H14CIN3O4S.H20 and its molecular weight is 385.8.

 

MECHANISM OF ACTION:
Cefaclor is a bactericidal cephalosporin and like other cephalosporins is an inhibitor of bacterial cell wall synthesis.  It acylates membrane-bound transpeptidase enzymes thus preventing the cross-linking of peptidoglycan necessary for bacterial cell wall strength and rigidity.

 

PHARMACOKINETICS:
Cefaclor is well absorbed after oral administration.  The presence of food may delay the absorption of cefaclor but the total amount absorbed remains unchanged.  Serum levels of 6mg/1 mcg and 13 mg/1 mcg are obtained after 250 mg and 500 mg of cefaclor, respectively.  Peak serum concentrations are obtained in 0.5 to 1 hour.  About 25% of the drug is protein bound.  Cefaclor is widely distributed in the body.  It is rapidly excreted by the kidneys, up to 85% of a dose appears unchanged in urine within two hours.  The plasma elimination half life cefaclor is about 30 minutes to 1 hour.

 

INDICATIONS:
Cefaclor is indicated in the treatment of respiratory tract infection, acute bronchitis and acute exacerbation of chronic bronchitis, pneumonia, otitis media, pharyngitis, tonsillitis, sinusitis, urinary tract infections and skin soft tissue infections.

 

PRECAUTION:
Risk versus benefit should be carefully considered when history of bleeding disorders, uncreative colitis, regional enteritis or pseudomembranous colitis exist.

 

SIDE EFFECTS:
The most common are hypersensitivity reactions, including skin rashes, urticaria, eosinophilia, fever reactions resembling serum sickness and anaphylaxis.

 

DOSAGE & ADMINISTRATION:
50 mg/mL Granules for Suspension(Oral Drops)

Children:
Over 1 month of age: 20 mg/kg body-weight daily in three divided doses, increased if necessary to 40 mg/kg daily but not exceeding a total daily dose of 1g or as prescribed by the physician.
250 mg/5mL Granules for Suspension

Over 5 years old: 5mL (1 teaspoonful) every 8 hours
1 year to 5 years old: 2.5 mL(1/2 teaspoon) every 8 hours or as prescribed by the physician.

 

DIRECTION FOR RECONSTITUTION:
To make 20 mL suspension, add 14 mL water
To make 60 mL suspension, add 42 mL water
Mix thoroughly until all granules are evenly suspended.
After reconstitution, suspension retains potency for 7 days at temperatures not exceeding 30oC and 14 days under refrigeration (2-8oC).

 

 

 

 

 

 

cefaclor

 

 

STORAGE CONDITION:
Store at temperature not exceeding 30oC
Shake well before using.

 

AVAILABILITY:
50 mg/mL Granules for Suspension(Oral Drops)
Amber Bottle – Bottle of 15mL & 20mL
250 mg/5mL Granules for Suspension
Amber Bottle – Bottle of 60mL

 

CAUTION:
Foods, Drugs, Devices and Cosmetics Acts prohibits dispensing without prescription.

 

 

cefaclor remedrol

 

 

Manufactured for:

Remed Pharmaceuticals, Inc.

AIC Burgundy Empire Tower

ADB Ave., corner Sapphire & Garnet Road

Ortigas Center, Pasig City 1605

 

By:

Lloyd Laboratories, Inc. #10 Lloyd Ave., First Bulacan Industrial City, City of Malolos, Bulacan