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CETIRIZINE - RHINITRIN

remed order

 

5 mg / 5 mL Syrup
Antihistamine

 

FORMULATION:
Each 5mL contains:
Cetirizine dihydrochloride
B.P. 5mg

 

MECHANISM OF ACTION:
Cetirizine is known as antihistamine that blocks those responses to histamine initiated by H1 receptor stimulus, thus acts as an effective anti-allergy drug.  It inhibits the immediate hypersensitivity response to antigen and prevents symptoms after nasal and conjunctival challenge with allergen.  It also inhibits in-vitro chemotaxis of eosinophils and secretion of toxic mediators by platelets.

 

PHARMACOKINETICS:
Cetirizine is rapidly absorbed from gastro-intestinal tract after oral administration, peak plasma concentrations being attained in about an hour.  Food delays the time to peak plasma concentrations but does not decrease the amount of drug absorbed.  It is highly bound to plasma proteins and has an elimination half-life of about 10 hours.  Cetirizine  has been detected in breast milk.  Cetirizine is excreted primarily in the urine mainly as unchanged drug.  It does not appear to cross the blood-brain barrier to a significant extent.

 

INDICATIONS:
For symptomatic relief of allergy such as hay fever and urticaria.

 

CONTRAINDICATIONS:
Hypersensitivity or idiosyncracy to Cetirizine or its parent compound, hydroxyzine.

 

DOSAGE AND ADMINISTRATION:
For children 2-6 years old:
5 mL once daily
For children above 6 years old:
10 mL once daily or
5 mL twice daily
In individual cases the 10 mL daily doses can be administered as 5 mL in the morning and 5 mL in the evening.

 

PRECAUTIONS:
Pregnancy, lactation, renal impairment, alcohol dependency, during driving or operating machinery.  Administration of antihistamines may sometimes cause rashes and hypersensitivity reactions (including bronchospasm, angioedema and anaphylaxis) and cross-sensitivity to related drugs may occur.

 

SIDE EFFECTS:
Drowsiness, headaches, dry mouth, dizziness, agitation and GI upset.

 

DRUG INTERACTIONS:
CNS depressants, no other interactions are reported so far.

 

 

cefaclor

 

CAUTIONS:
Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.

 

STORAGE:
Store at temperatures not exceeding 30oC.

 

AVAILABILITY:
In 30 mL bottle.

 

WARNING:
Keep out of reach of children.

 

 

 

Manufactured by:
Sigma Laboratories LTD.

 

Exclusively Distributed by:

Remed Pharmaceuticals, Inc.
AIC Burgundy Empire Tower
ADB Ave., corner Sapphire & Garnet Road
Ortigas Center, Pasig City 1605